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Alpha-Hederin

SKU: orb1222435

Description

alpha-Hederin is Derived from beta-amyrin; other hederigenin based saponins are available. It induces apoptosis in hepatocellular carcinoma cells.(In Vitro):alpha-Hederin (α-Hederin) is cytotoxic and inhibits proliferation in both cel lines at rather low concentrations. alpha-Hederin (α-Hederin)reduces the mitotic activity in treated cells.(In Vivo):alpha-Hederin (α-Hederin) has preventive effect on sensitized rats like thymoquinone. It may intervene in miRNA-126 expression, which consequently could interfere with IL-13 secretion pathway leading to a reduction in inflammatory responses.

Images & Validation

Key Properties

CAS Number27013-91-8
MW750.97
Purity>98% (HPLC)
FormulaC41H66O12
SMILESC[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]1[C@H]([C@H](CO[C@H]1O[C@H]1CC[C@]2([C@H]([C@]1(C)CO)CC[C@@]1([C@@H]2CC=C2[C@]1(CC[C@@]1([C@H]2CC(CC1)(C)C)C(=O)O)C)C)C)O)O)O)O)O
TargetOthers
SolubilityDMSO : ≥ 100 mg/mL 133.16 mM; H2O : < 0.1 mg/mL

Bioactivity

In Vivo
alpha-Hederin (α-Hederin) has preventive effect on sensitized rats like thymoquinone. It may intervene in miRNA-126 expression, which consequently could interfere with IL-13 secretion pathway leading to a reduction in inflammatory responses.
In Vitro
alpha-Hederin (α-Hederin) is cytotoxic and inhibits proliferation in both cel lines at rather low concentrations. alpha-Hederin (α-Hederin)reduces the mitotic activity in treated cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

alpha-Hederin

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Alpha-Hederin (orb1222435)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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100 mg
200 mg
500 mg
2 mg
$ 150.00
5 mg
$ 240.00
10 mg
$ 320.00
25 mg
$ 560.00