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Altiratinib

SKU: orb1306623

Description

Altiratinib (DCC-2701) is a multi-kinase inhibitor targeting c-MET, TIE-2, and VEGFR. It has been shown to inhibit c-MET phosphorylation, cell proliferation, and migration in vitro, and demonstrates efficacy in reducing tumor growth in vivo, supporting its investigation in oncology research.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number1345847-93-9
MW510.46
Purity99.75% (May vary between batches)
FormulaC26H21F3N4O4
SMILESFc1ccc(NC(=O)C2(CC2)C(=O)Nc2cc(F)c(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)cc1
TargetFLT,Trk receptor,c-Met/HGFR,VEGFR,Tie-2
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.92 mM);DMSO:240 mg/mL (470.16 mM)

Bioactivity

Target IC50
MET (Y1230C):0.37 nM|MET (Y1230C):1.2 nM|TrkA:0.85 nM|TrkC:0.85 nM|FLT3:9.3 nM|Tie2:8 nM|Trk3:0.93 nM|MET (D1228N):1.3 nM|Trk2:4.6 nM|VEGFR2:9.2 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Tie2, Tie-2, Trkreceptor, Tropomyosin related kinase receptor, Trk receptor, Trk Receptor, TrkA, TrkC, Vascular endothelial growth factor receptor, VEGFR, Inhibitor, HGFR, Fms like tyrosine kinase 3, FLT3, inhibit, DCC2701, DCC-2701, DCC 2701, c-Met/HGFR, cMet, c-Met, cMet/HGFR, Cluster of differentiation antigen 135, CD135, Altiratinib

Similar Products

  • Altiratinib [orb1226496]

    >98% (HPLC)

    1345847-93-9

    510.46

    C26H21F3N4O4

    200 mg, 100 mg, 5 mg, 10 mg, 25 mg, 50 mg, 1 g, 500 mg
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Key Properties

No computed properties available.

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Altiratinib (orb1306623)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 120.00
25 mg
$ 180.00
50 mg
$ 270.00
100 mg
$ 380.00
DispatchUsually dispatched within 3-5 working days
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