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AMG 511

SKU: orb1308665

Description

AMG 511

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number1253573-53-3
MW517.58
Purity≥98%
FormulaC22H28FN9O3S
SMILESCOc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)[C@H](C)N2CCN(CC2)S(C)(=O)=O)cc1F
TargetPI3K
SolubilityDMSO:33.33 mg/mL (64.4 mM)

Bioactivity

Target IC50
PI3Kδ:2 nM (ki)|PI3Kβ:6 nM (ki)|PI3Kα:4 nM (ki)|PI3Kγ:1 nM (ki)
In Vivo
AMG 511 shows excellent in vivo efficacy and pharmacokinetic profile. AMG 511 potently blocks the targeted PI3K pathway in a mouse liver pharmacodynamic model (3-30 mg/kg; p.o.). And it inhibits tumor growth in a U87 MG glioblastoma xenograft model (3-30 mg/kg; p.o.; daily; for 12 days).
In Vitro
AMG 511 inhibits AKT (Ser473) phosphorylation in U87 malignant glioma (MG) cells with an IC50 of 4 nM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PI3Kδ, PI3Kγ, PI3Kβ, PI3Kα, PI3K, Phosphoinositide 3-kinase, AMG511, AMG-511, AMG 511, inhibit, Inhibitor, malignant, glioma, glioblastoma

Similar Products

  • AMG 511 [orb1218988]

    >98% (HPLC)

    1253573-53-3

    517.6

    C22H28FN9O3S

    5 mg, 1 g, 500 mg, 200 mg, 100 mg, 2 mg
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Key Properties

No computed properties available.

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AMG 511 (orb1308665)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 130.00
2 mg
$ 150.00
5 mg
$ 200.00
1 ml x 10 mM (in DMSO)
$ 340.00