Amikacin disulfate

SKU: orb1300817

Description

Amikacin disulfate

Research Area

Infectious Disease & Virology

Images & Validation

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Item 1 of 1

Key Properties

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CAS Number	39831-55-5
MW	781.76
Purity	99.30%
Formula	C₂₂H₄₃N₅O₁₃·2H₂O₄S
SMILES	O=S(O)(O)=O.NCC[C@H](O)C(N[C@H](C[C@@H]([C@H]([C@@H]1O)O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CN)N)[C@@H]1O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)N)O)CO)=O.O=S(O)(O)=O
Target	Antibiotic,Antibacterial
Solubility	DMSO:Insoluble;H2O:100 mg/mL (127.92 mM)

Bioactivity

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In Vivo

Amikacin (80 mg/kg i.v.) significantly reduced pseudomonal densities within aortic vegetations compared to controls in the Experimental rabbit endocarditis model. In addition, amikacin given once daily is still more effective tha the twice-daily regimen. [7] Amikacin given alone at a dose of 50 mg/kg, in one, two, or three divided doses, showed remarkable activity in model of Mycobacterium avium complex infections in beige mice. Addition of clofazimine increase the activity significantly. [8]

In Vitro

Amikacin sulfate has high affinities for 16S rRNA o the bacterial 30S ribosome, causing misreading of mRNA and leavin the bacterium unable to synthesize proteins vital to its growth. Amikacin is active in vitro against Pseudomonas species, Escherichia col , Proteus species (indole-positive and indole-negative), Providencia species, Klebsiella-Enterobacter-Serratia species, Acinetobacter (formerly Mima-Herellea) species, and Citrobacter freundii in vitro studies have shown that amikacin sulfate combined with a beta-lactam antibiotic acts synergistically against many clinically significant Gram-negative organisms. In vitro studies have shown that amikacin sulfate combined with beta-lactam antimicrobial agents including moxalactam or piperacillin acts synergistically against many clinically significant Gram-negative organisms.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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protein, Pierami, ribosomal, synthesis, aminoglycosides, Antibiotic, Antimicrobial, Bacterial, bacillary, BB-K8, BAY416651 Sulfate, BAY-416651 Sulfate, BAY-416651 sulfate, BAY 41-6551 disulfate, BAY 416651 Sulfate, Amikacin, Amikacin disulfate, Amikacin Disulfate, Amikacin Sulfate, Amikacin sulfate, 16S rRNA, inhibit, Inhibitor, kanamycin, infections, ototoxic, Gram-negative

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Chemical Structure of Amikacin disulfate.

Compound Identifiers

PubChem CID

38351 ↗

Key Properties

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No computed properties available.

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