β-Aminoarteether

SKU: orb1691819

Description

β-Aminoarteether (SM934 free base) is an orally bioavailable artemisinin derivative used in research on inflammation and autoimmune diseases, such as lupus. Studies demonstrate its immunomodulatory activity in both in vitro cellular assays and in vivo animal models of autoimmunity.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	133162-24-0
MW	327.42
Purity	96.09%
Formula	C₁₇H₂₉NO₅
SMILES	C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(O[C@@H]1OCCN)[H])[H]
Target	NOD-like Receptor (NLR),Others
Solubility	DMSO:60 mg/mL (183.25 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.11 mM)

Bioactivity

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In Vivo

Treatment with β-Aminoarteether (SM934; orally administered at doses of 1-10 mg/kg daily for 3 months) substantially slowed the advancement of glomerulonephritis and enhanced survival rates in female NZB/W F1 mice aged six and a half months . Additionally, β-Aminoarteether therapy bolstered the production of IL-10 by macrophages derived from these mice . This indicates a promising therapeutic potential for managing glomerulonephritis in this mouse model.

Storage & Handling

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Storage	Pure form: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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SM 934, SM934, SM-934, SM934 free base, β-Aminoarteether, b-Aminoarteether, beta-Aminoarteether

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Compound Identifiers

PubChem CID

10019350 ↗

Key Properties

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No computed properties available.

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