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Anatibant 2HCl

SKU: orb1819277

Description

Anatibant 2HCl is a selective bradykinin B2 receptor antagonist used in neuroscience research. It is applied in both in vitro binding assays and in vivo models to study its potential neuroprotective effects in conditions such as traumatic brain injury and stroke.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number209788-45-4
MW784.58
Purity99.58%
FormulaC34H36Cl2N6O5S.2ClH
SMILESClC(C(S(=O)(N1[C@@H](CCC1)C(NCCCNC(C2=CC=C(C=C2)C(N)=N)=O)=O)=O)=CC=C3Cl)=C3COC4=CC=CC5=C4N=C(C)C=C5C.Cl.Cl
TargetBradykinin Receptor
SolubilityDMSO:55 mg/mL (70.1 mM)

Bioactivity

Target IC50
Bradykinin receptor B2:1.74 nM (Ki, rat recombinant B2 receptor)|Bradykinin receptor B2:1.37 nM (Ki, guinea-pig recombinant B2 receptor)|Bradykinin receptor B2:0.67 nM (Ki, human recombinant B2 receptor)
In Vivo
Anatibant (3.0 mg/kg b.w.; Subcutaneous Injection; Male C57/Bl6 mice (CCI)) was administrated as a subcutaneous bolus 15 min and 8h after TBI. ICP was measured 3, 6, and 10 h after injury, and contusion volume was quantified 24 h after trauma. Our data demonstrate a significant reduction of ICP (16.6+/-1.67 mmHg vs. 24.40+/-3.58 mmHg; n=6; p=0.002) and of contusion volume 24 h after trauma (28.28+/-5.18 mm3 vs. 35.0+/-3.32 mm3 n=7; p=0.003) in treated mice. Therefore we conclude, that inhibition of bradykinin B2 receptors seems to be a promising treatment option, and might therefore be investigated in clinical trials for the treatment of TBI.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Anatibant, Anatibant 2HCl, Anatibant 2HCl(209733-45-9 Free base), bradykinin B2, Bradykinin Receptor, BradykininReceptor
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Key Properties

No computed properties available.

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Anatibant 2HCl (orb1819277)

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% DMSO +
%+
% Tween 80 +
%

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1 mg
$ 390.00
5 mg
$ 870.00
10 mg
$ 1,240.00
25 mg
$ 1,630.00
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