Andecaliximab Antibody

SKU: orb1980587

Description

Andecaliximab is a recombinant IgG4 monoclonal antibody targeting MMP9, demonstrating antifibrotic effects in murine IPF models. It serves as a research tool for studying gastric adenocarcinoma, idiopathic pulmonary fibrosis, and dengue virus infection in both in vivo and in vitro experimental systems.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	1518996-49-0
MW	150 kDa
Purity	> 95%
Target	Virus Protease,MMP

Bioactivity

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In Vivo	Improving the diversity of T cell receptor (TCR) in tumor-infiltrating T cells, andecaliximab. In a human NSG mouse model of idiopathic pulmonary fibrosis, andecaliximab (20 mg/kg; intraperitoneal injection, single) exhibited an anti-fibrosis effect. Read more...
In Vitro	Andecaliximab increases serum IL-7 levels [ 1 ]. Andecaliximab ( 50 μg / mL ; 24 h ) reduced the phosphorylation of SMAD2 ( pSMAD2 ) in ABC cell lines [ 2 ]. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Andecaliximab, Dengue Fever virus, GS 5745, GS5745, GS-5745, MMP-9, Virus Protease, VirusProtease

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Gene Symbol

Virus Protease,MMP

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