Antitumor agent-200

SKU: orb3028675

Description

Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor that binds to the colchicine site on tubulin, causing G2/M cell cycle arrest and inducing reactive oxygen species (ROS) production. It demonstrates significant inhibitory activity against P-glycoprotein (P-gp) overexpressing cell lines MCF7/ADR and KBV200, with resistance indices (DRI) of 0.83 and 0.58, respectively. In an MCF-7 xenograft model, Antitumor agent-200 (at 25 mg/kg, administered intraperitoneally) achieves a 57.2% tumor growth inhibition rate. This compound is applicable for research in the field of cancer therapy.

Research Area

Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

−

Key Properties

−

CAS Number	3046118-64-0
MW	423.34
Formula	C₁₉H₂₁FN₂O₃Se
SMILES	O=C(NCC1=CC=C([Se]C)C(O)=C1)C2=CC(F)=CC=C2N3CCOCC3
Target	P-gp,Microtubule Associated

Storage & Handling

−

Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Quick Database Links

Gene Symbol

P-gp,Microtubule Associated

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols