ARRB1 (N) Antibody, Rabbit Polyclonal

SKU: orb67279

Description

Rabbit polyclonal to ARRB1.Beta-arrestin-1 (ARRB1) is a cytosolic protein that belongs to the arrestin family. Beta arrestinsfunction in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediatingboth receptor desensitization and resensitization processes. It is involved in IL8-mediated granulerelease in neutrophils. Beta-arrestin-1 acts as a cofactor in the beta-adrenergic receptor kinase(BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, itis expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system isbelieved to play a major role in regulating receptor-mediated immune functions.

Research Area

Epigenetics

Images & Validation

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Item 1 of 1

Tested Applications	WB
Dilution Range	WB:1:1000-1:5000
Reactivity	Human

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	N-terminal region of human ARRB1
Molecular Weight	47
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Disclaimer	For research use only

Alternative Names

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anti-ARRB1 antibody,anti-Betaarrestin1 antibody,anti-Arrestin beta1 antibody,anti-ARR1 antibody

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Western blot of total cell extracts from human MCF7 using ARRB1 antibody

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UniProt

P49407

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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