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AS-2444697

SKU: orb1302973

Description

AS-2444697 is a potent and selective IRAK-4 inhibitor with an IC50 of 21 nM, demonstrating activity across human and rat enzymes. Its anti-inflammatory mechanism underlies observed renoprotective effects in research models, supporting its use in studying innate immune signaling pathways in both in vitro and in vivo contexts.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

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AS-2444697

Key Properties

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CAS Number1287665-60-4
MW432.86
Purity97.43% (May vary between batches)
FormulaC19H21ClN6O4
SMILESCl.Cc1cc(ccn1)-c1nc(co1)C(=O)Nc1cn(nc1C(N)=O)C1CCOCC1
TargetIRAK
SolubilityDMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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Target IC50
IRAK4:21 nM
In Vitro
AS-2444697 (0.3-3 mg/kg) significantly increases the plasma levels of IL-1β, IL-6, TNF-α, MCP-1, and aminotransferases (ALT and AST) in LPS/GalN-treated mice. Single administration of AS-2444697 (0.3-3 mg/kg) dose-dependently decreases plasma levels of these all parameters, and these effects were significant at doses of 1 mg/kg or higher. After oral administration of AS-2444697 (3 mg/kg) to 5/6 Nx rats, plasma, and tissue (liver and kidney) concentrations of the unchanged drug peaked at 1 h and then gradually decreased, with a terminal half-life of 2.7-2.9 h. AS-2444697 is efficacious in the rat adjuvant-induced arthritis (ED50 2.7 mg/kg, BID, PO) and the rat collagen-induced arthritis (ED50 1.6 mg/kg, BID, PO) disease models. Good bioavailability was seen in rat (F% 50) and dog (F% 78) pharmacokinetic studies.
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Storage & Handling

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StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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AS2444697, AS-2444697, AS 2444697, anti-inflammatory, Inhibitor, IRAK, IRAK-4, IL-1R associated kinase, Interleukin-1 receptor associated kinase, inhibit, renoprotective

Similar Products

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  • AS 2444697

    AS 2444697 [orb1941100]

    >98% (HPLC)

    1287665-60-4

    432.865

    C19H21ClN6O4

    1 g, 500 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg
Quality Guarantee

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Compound Identifiers

PubChem CID
118719434 ↗

Key Properties

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No computed properties available.

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AS-2444697 (orb1302973)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 70.00
5 mg
$ 130.00
10 mg
$ 180.00
25 mg
$ 320.00
50 mg
$ 500.00
100 mg
$ 830.00
200 mg
$ 1,110.00
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