AS601245

A potent and selective inhibitor of JNK with IC50s of 70/220/150 nM for JNK1/2/3 respectively; less potent for c-Src, c-Raf, p38a; exhibits in vitro and in vivo anti-inflammatory potential.(In Vitro):AS601245, an anti-Inflammatory JNK inhibitor, and Clofibrate have a synergistic effect in inducing cell responses and in affecting the gene expression profile in CaCo-2 colon cancer cells .(In Vivo):AS601245 (40, 60, and 80 mg/kg; i.p.) provides significant protection against the delayed loss of hippocampal CA1 neurons in a gerbil model of transient global ischemia.AS601245 (0.3-10 mg/kg; p.o.) is a potent inhibitor of LPS-induced TNF-α release in mice.