Asperulosidic acid

SKU: orb1218276

Description

Asperulosidic acid has anti-tumor, anti-oxidant, and anti-inflammatory activities.ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways.

Images & Validation

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Key Properties

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CAS Number	25368-11-0
MW	432.4
Purity	>98% (HPLC)
Formula	C₁₈H₂₄O₁₂
SMILES	OC[C@H]([C@@H](O)[C@H](O)[C@H]1O)O[C@@]1([H])O[C@H]2[C@@]3([H])[C@@]([C@@H](O)C=C3COC(C)=O)([H])C(C(O)=O)=CO2
Target	ERK
Solubility	In Vitro: DMSO : 100 mg/mL (231.28 mM)

Bioactivity

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In Vitro

Asperulosidic Acid (ASPA) (40-160 μg/mL; pre- 1 hour) significantly down-regulates the mRNA levels of TNF-α and IL-6 in LPS-induced RAW 264.7 cells compared with the group treated with LPS alone. Asperulosidic Acid (ASPA) (40-160 μg/mL; pre- 1 hour) decreases IκB-α phosphorylation in a concentration-dependent manner, decreases Erk1/2 phosphorylation at all concentration levels, but there was no effect on p-p38. RT-PCR Cell line: RAW 264.7 cells Concentration: 40 μg/mL, 80 μg/mL, and 160 μg/mL. Incubation time: Pre-treatment 1 hour. Result: Decreased TNF-α and IL-6 mRNA expression. Western blot analysis. Cell line: RAW 264.7 cells Concentration: 40 μg/mL, 80 μg/mL, and 160 μg/mL. Incubation time: Pre-treatment 1 hour. Result: Decreased IκB-α phosphorylationand Erk1/2 phosphorylation.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ASPA

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Gene Symbol

ERK

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