Aurantiamide

SKU: orb1301466

Description

Aurantiamide exhibits anti-cancer, anti-inflammatory, and antinociceptive properties. Its mechanisms include blocking autophagic flux to suppress glioma growth and inhibiting NF-κB, JNK, and p38 pathways to counteract neuroinflammation. This small molecule is a useful research tool for neuroscience and oncology studies in both in vitro and in vivo models.

Research Area

Cell Biology, Signal Transduction

Images & Validation

−

Key Properties

−

CAS Number	58115-31-4
MW	402.49
Purity	98.88%
Formula	C₂₅H₂₆N₂O₃
SMILES	OC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1
Target	NF-κB,p38 MAPK,RIP kinase,MLK
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.2 mM);DMSO:100 mg/mL (248.45 mM)

Bioactivity

−

In Vitro

Aurantiamide was shown to block the activation of nuclear factor-kappa B (NF-κB) in lipopolysaccharide (LPS)-induced BV2 microglial cells by inhibiting the phosphorylation of the inhibitor kappa B-α (IκB)-α. Aurantiamide decreased the phosphorylation levels of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases (MAPKs).Suggested that aurantiamide has an anti-neuroinflammatory effect on LPS stimulation through its inhibition of the NF-κB, JNK and p38 pathways.Aurantiamide has potent anti-viral and anti-inflammatory effects on IAV-infected cells via inhibition of the NF-κB pathway. Therefore ,Aurantiamide could be a potential therapeutic agent for the treatment of influenza.

Cell Research

The anti-viral activity of aurantiamide against Influenza A virus (IAV) was determined using the cytopathic effect (CPE) inhibition assay. Viruses were titrated on Madin-Darby canine kidney (MDCK) cells by plaque assays. Ribonucleoprotein (RNP) luciferase reporter assay was further conducted to investigate the effect of aurantiamide on the activity of the viral polymerase complex. HEK293T cells with a stably transfected NF-κB luciferase reporter plasmid were employed to examine the activity of aurantiamide on NF-κB activation. Activation of the host signaling pathway induced by IAV infection in the absence or presence of aurantiamide was assessed by western blotting. The effect of aurantiamide on IAV-induced expression of pro-inflammatory cytokines was measured by real-time quantitative PCR and Luminex assays.

Storage & Handling

−

Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

p38 MAPK, p38, p38MAPK, TMC-58B, NFκB, NF-kB, NFkB, NF-κB, Inhibitor, inhibit, antioxidant, anti-inflammatory, antiplatelet, antitumor, Aurantiamide

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

185904 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Aurantiamide (orb1301466)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

Purity:	99.68%
CAS Number:	56121-42-7
MW:	444.52
Formula:	C₂₇H₂₈N₂O₄

MW:	506.602
Formula:	C₃₂H₃₀N₂O₄

Purity:	>98% (HPLC)
CAS Number:	58115-31-4
MW:	402.5
Formula:	C₂₅H₂₆N₂O₃

Aurantiamide

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Aurantiamide acetate [orb1297667]

Aurantiamide benzoate [orb1991068]

Aurantiamide [orb1220702]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Aurantiamide (orb1301466)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors