Avibactam sodium hydrate

SKU: orb1909009

Description

Avibactam sodium hydrate (NXL-104 hydrate) is a β-lactamase inhibitor effective against class A enzymes, including TEM-1, CTX-M-15, and KPC carbapenemases. It is widely used in research to study antibiotic resistance mechanisms and to restore the efficacy of β-lactam antibiotics in both in vitro and in vivo models.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	2938989-90-1
MW	305.24
Purity	99.95%
Formula	C₇H₁₂N₃NaO₇S
SMILES	NC([C@H]1[N@@]2C(N([C@@](CC1)([H])C2)OS(=O)([O-])=O)=O)=O.[Na+].O
Target	Antibiotic,Antibacterial
Solubility	H2O:150 mg/mL (491.42 mM)

Bioactivity

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Target IC50	TEM1:8 nM\|CTX-M-15:5 nM
In Vivo	In a mouse model infected with K. pneumoniae Y8 strain, Avibactam sodium hydrate in combination with ceftazidime (0.375 mg/g; subcutaneous injection; every 8 hours for 10 days) significantly inhibited bacterial growth and demonstrated some therapeutic effect. After a single subcutaneous injection of Avibactam sodium hydrate (64 mg/kg), its estimated mean terminal half-life against Pseudomonas aeruginosa infection in a neutropenic mouse lung infection model was 0.24 hours. Read more...
In Vitro	Avibactam sodium hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor with IC50 values of 8 nM and 5 nM for the β-lactamases TEM-1 and CTX-M-15, respectively. Although Avibactam sodium hydrate has little or no antimicrobial activity, it effectively inhibits class A and C β-lactamases, and has no significant effect on the activities of metallo-β-lactamases and Fusobacterium oxysporum OXA carbapenemase. When Avibactam sodium hydrate was used in combination with ceftazidime (concentration range 0-256 mg/L), it inhibited the growth of 16 blaKPC-2-positive and 1 blaOXA-232-positive strains of K. pneumoniae with MIC50 and MIC90 of 8 mg/L. Read more...

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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NXL-104 hydrate

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Compound Identifiers

PubChem CID

118704750 ↗

Key Properties

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No computed properties available.

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