BC-1215

SKU: orb1301459

Description

BC-1215 is a potent small molecule inhibitor of the E3 ubiquitin ligase component FBXO3, demonstrating an IC50 of 0.9 μg/mL for inhibiting IL-1β release. This compound is a valuable research tool for studying inflammatory pathways and has been utilized in both cellular and animal models to investigate diseases driven by dysregulated proteasomal degradation.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1507370-20-8
MW	394.51
Purity	98.00%
Formula	C₂₆H₂₆N₄
SMILES	C(CNCc1ccc(cc1)-c1ccccn1)NCc1ccc(cc1)-c1ccccn1
Target	Ligands for E3 Ligase,E3 Ligase Ligand-Linker Conjugates
Solubility	DMSO:3.95 mg/mL (10.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.53 mM)

Bioactivity

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Target IC50	FBXO3:0.9 μg/mL
In Vivo	A small molecule inhibitor BC-1215 argeting Fbxo3 was sufficient to lessen severity of cytokine-driven inflammation in several murine disease models.
Animal Research	Tested effects of administration of BC-1215 in a model of a cecal ligation and puncture (CLP)-induced sepsis. Mice with CLP had significantly increased cytokine release compared to sham treated mice. BC-1215 treatment significantly attenuated CLP-induced secretion of all three circulating pro-inflammatory cytokines in mice . BC-1215 also decreased bacterial counts in the CLP model and modestly produced inhibition of bacterial growth using Kirby Bauer testing Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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TRAF, U937 cells, E3 ligase-recruiting Moiety, BC1215, BC-1215, BC 1215, FBXO3, F-box protein 3 (Fbxo3), Inhibitor, PBMC cells, MLE cells, LigandforE3Ligase, Ligands for E3 Ligase, Ligand for E3 Ligase, inhibit, inflammation

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Compound Identifiers

PubChem CID

72201045 ↗

Key Properties

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No computed properties available.

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BC-1215 (orb1301459)

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Purity:	>98% (HPLC)
CAS Number:	1507370-20-8
MW:	394.522
Formula:	C₂₆H₂₆N₄

BC-1215

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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