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beta-Amyrone

SKU: orb1297121

Description

β-Amyrone is a bioactive small molecule with antiviral activity against Chikungunya virus (EC50 = 86 µM), anti-inflammatory effects via COX-2 suppression, and inhibitory activity against α-glucosidase and AChE. It is a useful research tool for studying viral infections, inflammatory processes, and metabolic disorders like obesity.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Neuroscience

Images & Validation

Key Properties

CAS Number638-97-1
MW424.7
Purity99.95%
FormulaC30H48O
SMILESCC1(C)CCC2(C)CCC3(C)C(=CCC4C5(C)CCC(=O)C(C)(C)C5CCC34C)C2C1
TargetAChR,Antifection,COX,Antifungal,PPAR
SolubilityEthanol:< 0.1 mg/ml (insoluble);DMSO:4.25 mg/mL (10.01 mM)

Bioactivity

In Vivo
In ear phenol-induced edema in Balb C mice, beta-Amyrone (0.1, 0.3, 0.6 mg/kg) inhibits ear edema formation in a dose-related manner.
In Vitro
beta-Amyrone inhibits α-glucosidase AChE and fungal activity with IC50 values of 25 μM, 23 μM and 8 μg/mL, respectively. In LPS-stimulated J774 cells, beta-Amyrone (2.5, 5, 10 μg/mL) inhibits NO production with an IC50 value of 4.61 μg/mL without obvious effects on cell viability. beta-Amyrone (10 μg/mL) inhibits IL-6, IL-10 levels, and COX-2 expression at the dose of 10 μg/mL.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

COX-2, COX, Cyclooxygenase, beta-Amyron, beta-Amyrone, CHIKV, AChE, AChR, b-Amyron, b-Amyrone, Anti-inflammatory, Antifection, antifungal, Fungal, Inhibitor, obesity, infection, inflammation, inhibit, β-Amyrone, β-Amyron, Peroxisome proliferator-activated receptors, PPAR, PI3K-Akt

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Key Properties

No computed properties available.

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beta-Amyrone (orb1297121)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 170.00
5 mg
$ 420.00
10 mg
$ 640.00
25 mg
$ 980.00
50 mg
$ 1,300.00
100 mg
$ 1,730.00
500 mg
$ 3,420.00
DispatchUsually dispatched within 3-5 working days
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