Bisacodyl

SKU: orb1300788

Description

Bisacodyl is a diphenylmethane derivative used as a stimulant laxative to relieve constipation and prepare the bowel for procedures. It is employed in pharmacological research to study colonic motility and secretory mechanisms in both in vivo and in vitro experimental models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	603-50-9
MW	361.39
Purity	99.78%
Formula	C₂₂H₁₉NO₄
SMILES	C(C1=CC=C(OC(C)=O)C=C1)(C2=CC=C(OC(C)=O)C=C2)C3=CC=CC=N3
Target	Opioid Receptor,Others,Dopamine Receptor
Solubility	DMSO:55 mg/mL (152.19 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.53 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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In Vivo

At a concentration of 10 μg/mL, Bisacodyl acts on Raw264.7 cells, leading to an increase in the mRNA expression levels of TNF-α, COX2, and PGE2.

In Vitro

Bisacodyl inhibits the absorption of water in rats' jejunum, ileum, and colon, with the degree of inhibition linearly correlated to the logarithm of bisacodyl concentration. At a dosage of 4.3 mg/kg, bisacodyl, in combination with AOM, increases the number of microcysts per colony in rats without increasing tumor numbers. However, a higher dosage of 43 mg/kg significantly raises both the microcyst and tumor counts. Compared to rats treated with saline, bisacodyl (5.9 mg/kg) significantly reduces the activity of jejunum and colon (Na + K) ATPases. Furthermore, at 5.9 mg/kg, bisacodyl markedly increases PGE2 levels and stimulates adenylate cyclase activity in the jejunum and colon, without affecting cAMP levels. Oral administration of 10 mg/kg bisacodyl significantly decreases NOS activity in the rat jejunum. Meanwhile, 20 mg/kg bisacodyl leads to a reduction in AQP3 protein expression and an increase in TNF-α mRNA expression levels in the rat colon.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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DAT, Dulcolax, Dopamine Transporter, Bisacodyl, Brocalax, Opioid Receptor, inhibit, Inhibitor, Fenilaxan, SLC6A3

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Compound Identifiers

PubChem CID

2391 ↗

Key Properties

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No computed properties available.

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Bisacodyl (orb1300788)

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Purity:	99.79% (May vary between batches)
CAS Number:	586-98-1
MW:	109.13
Formula:	C₆H₇NO

CAS Number:	603-41-8
MW:	277.32
Formula:	C₁₈H₁₅NO₂

Purity:	>98% (HPLC)
CAS Number:	10040-45-6
MW:	481.41
Formula:	C₁₈H₁₅NO₈S₂·2Na

Purity:	>98% (HPLC)
CAS Number:	603-50-9
MW:	361.39
Formula:	C₂₂H₁₉NO₄

Bisacodyl

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Key Properties

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Bisacodyl (orb1300788)

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