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BMS-345541 free base

SKU: orb1225032

Description

A potent and selective IKK-2 inhibitor with IC50 of 0.3 uM; less potent for IKK-1 (IC40=4 uM) and no activity against IKK-ε; inhibits LPS-stimulated TNFα, IL-1β, IL-8, and IL-6 in THP-1 cells with IC50 of1-5 uM; has excellent pharmacokinetics in mice.

Images & Validation

Key Properties

CAS Number445430-58-0
MW255.3183
Purity>98% (HPLC)
FormulaC14H17N5
SMILESCc1ccc2c(c1)n3c(cnc3c(n2)NCCN)C
TargetIκB kinase (IKK)
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BMS345541 (free base)

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  • BMS-345541 [orb1300867]

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BMS-345541 free base (orb1225032)

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Available Sizes

Select a size below

500 mg
2 mg
$ 90.00
5 mg
$ 130.00
10 mg
$ 180.00
25 mg
$ 320.00
50 mg
$ 510.00
100 mg
$ 730.00
200 mg
$ 1,030.00