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BMS-833923

SKU: orb1305757

Description

BMS-833923 (XL-139) is a potent, orally bioavailable antagonist of the Smoothened (SMO) receptor, exhibiting an IC50 of 21 nM in displacing BODIPY-cyclopamine. This small molecule is a valuable tool for investigating Hedgehog pathway signaling in both cellular and animal models of cancer and developmental biology.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1059734-66-5
MW473.57
Purity99.76% (May vary between batches)
FormulaC30H27N5O
SMILESCNCc1ccc(C)c(NC(=O)c2ccc(Nc3nc(-c4ccccc4)c4ccccc4n3)cc2)c1
TargetApoptosis,Smo,Hedgehog/Smoothened
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.97 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:88 mg/mL (185.82 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

Target IC50
BODIPY:21 nM
In Vivo
BMS-833923 dose-dependently affected the transcription of prostate hedgehog signaling genes in vitro.BMS-833923 caused a decrease in hedgehog pathway activity, reduced cell proliferation, and induced apoptosis in esophageal adenocarcinoma cell lines via an endogenous pathway.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Smo, Smoothened, XL139, XL-139, XL 139, Hedgehog, inhibit, Inhibitor, Apoptosis, BMS833923, BMS-833923, BMS 833923

Similar Products

  • BMS-833923 [orb1222894]

    >98% (HPLC)

    1059734-66-5

    473.57

    C30H27N5O

    5 mg, 50 mg, 1 g, 500 mg, 10 mg, 25 mg, 100 mg, 200 mg
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Key Properties

No computed properties available.

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Protocol Information

BMS-833923 (orb1305757)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 120.00
25 mg
$ 170.00
50 mg
$ 250.00
100 mg
$ 420.00
200 mg
$ 600.00
500 mg
$ 920.00
DispatchUsually dispatched within 3-5 working days
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