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BMSpep-57

SKU: orb1691564

Description

BMSpep-57 is a potent macrocyclic peptide that competitively inhibits the PD-1/PD-L1 interaction with an IC50 of 7.68 nM and high binding affinity. It enhances T-cell function by promoting IL-2 production in PBMCs, making it a valuable tool for in vitro immuno-oncology research, including T-cell activation and immune checkpoint blockade studies.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

Key Properties

TargetPD-1/PD-L1
CAS Number1629655-80-6
MW1868.2
FormulaC89H126N24O19S
SMILES[H][C@@]12CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)CSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC2=O)C(=O)NCC(N)=O

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Protocol Information

Protein Handling and Storage Guide
Protein Handling Guide
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BMSpep-57 (orb1691564)

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