Briakinumab Antibody

SKU: orb1980509

Description

Briakinumab (ABT-874) is a human monoclonal antibody designed to neutralize interleukin-12 (IL-12). It has been investigated in preclinical and clinical research for immune-mediated conditions, including psoriasis, inflammatory bowel disease, and multiple sclerosis, through both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation

Images & Validation

−

Key Properties

−

CAS Number	339308-60-0
MW	143.86 kDa
Purity	99.53% (SEC-HPLC)
Target	IL Receptor,Interleukin

Bioactivity

−

Target IC50	FcRn:0.27 μM (Kd)
In Vivo	Administering Briakinumab to FcRn knockout (KO) mice via a tail vein, the Briakinumab treated group showed faster clearance compared to wild-type mice. Read more...
In Vitro	The affinity of Briakinumab to FcRn was Kd = 0.27μM.

Storage & Handling

−

Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

J 695, ABT874, ABT-874, A-796874.0, BSF415977, BSF 415977

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Quick Database Links

Gene Symbol

IL Receptor,Interleukin

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols