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BW-A 78U

SKU: orb1302090

Description

BW-A 78U is a selective PDE4 inhibitor with an IC50 of 3 μM. This compound does not suppress LPS-induced TNF-α release, making it a useful tool for studying PDE4-specific pathways in cellular inflammation models without broad cytokine interference.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number101155-02-6
MW257.27
Purity99.65% (May vary between batches)
FormulaC13H12FN5
SMILESCNc1ncnc2n(Cc3ccccc3F)cnc12
TargetPDE
SolubilityDMSO:45 mg/mL (174.91 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.77 mM)

Bioactivity

Target IC50
PDE4:3 μM
Cell Research
Mononuclear cells were incubated for 30 min with BW-A 78U (0.01-10 μM). The cells were then stimulated with lipopolysaccharide (10 μg/mL) overnight at 37°C in an atmosphere of 5% CO2 at 100% humidity. Cell-free supernatants were collected, centrifuged (2000 g), and stored frozen at -20°C before TNF-α determination. TNF-α concentrations in cell culture supernatants were determined by specific ELISA using a commercial kit. The sensitivity of the assay was 1 pg/mL. The absorbance at 450 nm was assessed with an ELISA reader.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PDE4, inhibit, Inhibitor, BW A 78U, BWA 78U, BW-A 78U, BW-A78U, phosphodiesterase, Phosphodiesterase (PDE)

Similar Products

  • BW-A78U [orb1221192]

    >98% (HPLC)

    101155-02-6

    257.27

    C13H12FN5

    2 mg, 25 mg, 5 mg, 100 mg, 1 g, 500 mg, 200 mg, 10 mg, 50 mg
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Key Properties

No computed properties available.

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BW-A 78U (orb1302090)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 80.00
5 mg
$ 150.00
10 mg
$ 200.00
25 mg
$ 310.00
50 mg
$ 420.00
100 mg
$ 580.00
200 mg
$ 780.00
DispatchUsually dispatched within 3-5 working days
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