Cabiralizumab Antibody

SKU: orb1980657

Description

Cabiralizumab (FPA 008) is an anti-CSF1R monoclonal antibody that enhances antitumor immunity by promoting T cell infiltration and inhibiting osteoclast-mediated bone destruction. It has been studied in rheumatoid arthritis research and investigated in immune-oncology, including in vivo and in vitro studies for lung cancer in combination with checkpoint inhibitors.

Research Area

Signal Transduction

Images & Validation

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Key Properties

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CAS Number	1613144-80-1
MW	146.30 kDa
Purity	95.00%
Target	c-Fms

Bioactivity

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In Vivo

Methods: Cabiralizumab (200, 400 μg, twice weekly for 5 doses) was administered intraperitoneally to YUMMER1.7 and YUMM1.7 murine melanoma models to evaluate its effects on tumor growth and survival. Single-cell RNA sequencing (scRNA-seq) was employed to analyze changes in macrophage subsets within tumor tissues. Results: High-dose Cabiralizumab treatment accelerated tumor growth and shortened survival, increased the abundance of CD163+ cells (immunosuppressive TAMs) in tumors, elevated the proportion of immunosuppressive TAM-II populations, and upregulated chemokine levels (e.g., CXCL2 and CCL3) that recruit immunosuppressive cells.

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Anti-Human CSF1R Recombinant Antibody, FPA 008, FPA008

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Gene Symbol

c-Fms

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