Camostat mesylate

SKU: orb1305552

Description

Camostat mesylate

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	59721-29-8
MW	494.52
Purity	99.85%
Formula	C₂₁H₂₆N₄O₈S
SMILES	CS(O)(=O)=O.CN(C)C(=O)COC(=O)Cc1ccc(OC(=O)c2ccc(NC(N)=N)cc2)cc1
Target	Sodium Channel,Serine/threonin kinase,SARS-CoV,Serine Protease
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.04 mM);DMSO:250 mg/mL (505.54 mM);H2O:49.5 mg/mL (100.1 mM)

Bioactivity

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Target IC50	ENaC:50 nM
In Vivo	At a concentration of 2 mM Camostat mesilate inhibit the production of MCP-1 and TNF-α in activated rat monocytes an the proliferation of rat pancreatic stellate cells (PSCs) along with MCP-1 production. in the presence of 20 mM Camostat mesilate, there is a notable reduction in blood glucose levels when combined with Insulin and administered vi the large intestine, effectively decreasing Insulin degradation in the rat's s All intestine and its homogenate. A 30 μM concentration of Camostat prolong the decay of ENaC function in a human respiratory epithelial cell model, which can be reversed by adding excess trypsin. At 500 mM, Camostat mesilate inhibit the generation of TGF-β by suppressing plasmin activity and reduce the activity of TGF-beta, thereby blockin the ex vivo activation of hepatic stellate cells (HSC). Read more...
In Vitro	Camostat mesilate, at a concentration of 1 mg/g, is effective in preventing pancreatic atrophy and improving exocrine function in rats with DBTC-induced chronic pancreatitis. This compound also inhibits chronic inflammation and fibrosis in the pancreas caused by DBTC. It suppresse the development of pancreatic fibrosis and PSC activation, as well as monocyte infiltration an the expression of MCP-1 in serum and pancreatic tissues. When administered at a dose of 100 mg/kg, Camostat mesilate significantly increases body and pancreatic wet weight, and effectively reduces inflammatory Changes and fibrosis in the pancreas by inhibiting gene expression of PAP, p8, and cytokines in chronic pancreatitis. In rats treated with pig serum, Camostat mesilate (1-2 mg/g in diet) notably decrease the levels of hepatic plasmin and TGF-β and inhibits HSC activation and liver fibrosis, without noticeable systemic or local side effects. Additionally, at a dose of 100 μg/kg intratracheally, Camostat prolong the attenuation of ENaC activity in guinea pig tracheas. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Camostat, Camostat mesilate, Camostat Mesylate, Camostat mesylate, coronavirus, chronic, pancreatitis, oral, inhibit, Inhibitor, FOY 305, FOY305, FOY-305, FOY-S 980, FOY-S980, FOY-S-980, epithelial sodium channel (ENaC), Serinekinase, threonin kinase, threoninkinase, Threonine proteases, Serine endopeptidases, Serine kinase, Ser/Thr Protease, Serine proteases, TMPRSS2, SARS coronavirus, SARSCoV, SARS-CoV, Sodium Channel, SodiumChannel, virus

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Compound Identifiers

PubChem CID

5284360 ↗

Key Properties

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No computed properties available.

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