Canakinumab Antibody

SKU: orb1983526

Description

Canakinumab (ACZ885) is a recombinant human monoclonal antibody that potently neutralizes IL-1β, exhibiting anti-inflammatory effects in both in vitro assays and in vivo models of autoimmune and cardiovascular diseases. Its application extends to research areas including gout, atherosclerosis, and cytokine-driven inflammation.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	914613-48-2
MW	145.18 kDa
Purity	98.8% (SDS-PAGE); 98.3% (SEC-HPLC)
Target	Interleukin,IL Receptor

Bioactivity

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Target IC50	IL-1β:43.6 pM (human)\|IL-1β:40.8 pM (marmoset)
In Vitro	Dose-dependently, Canakinumab (0-7 nM) represses IL-6 production in marmoset peripheral blood mononuclear cells, demonstrating IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. Effectively, Canakinumab competes with IL-1RI and IL-1RII for binding to IL-1b. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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IL Receptor, IL-1β, ILReceptor, Ilaris, ACZ 885

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Gene Symbol

Interleukin,IL Receptor

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