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CAY10602

SKU: orb1222310

Description

CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.

Images & Validation

Key Properties

CAS Number374922-43-7
MW418.44
Purity>98% (HPLC)
FormulaC22H15FN4O2S
SMILESFc1ccc(cc1)n1c2nc3ccccc3nc2c(c1N)S(=O)(=O)c1ccccc1
TargetSIRT1
SolubilityDMSO : 100 mg/mL 238.98 mM

Bioactivity

In Vitro
Compounds (including CAY10602/compound 1) with SIRT1-activating properties have a significant effect on fat mobilization in differentiated adipocytes, and these compounds (including CAY10602) have antiobesity and/or antidiabetic properties. Compounds (including CAY10602) with SIRT1 activating potential exert strong suppression of TNF-α release at concentrations between 20 and 60 μM.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CAY10602 | CAY-10602 | CAY 10602

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    418.44

    C22H15FN4O2S

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)
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CAY10602 (orb1222310)

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200 mg
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5 mg
$ 90.00
10 mg
$ 110.00
25 mg
$ 160.00
50 mg
$ 270.00
100 mg
$ 450.00