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CCF642

SKU: orb1223142

Description

CCF-642 is a protein disulfide isomerase (PDI) inhibitor. CCF642 exhibited a submicromolar IC50 in 10 of 10 multiple myeloma cell lines. In vitro, CCF642 inhibited PDI reductase activity about 100-fold more potently than the structurally distinct established inhibitors PACMA 31 and LOC14. CCF642 displayed potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolonged the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib.

Images & Validation

Key Properties

CAS Number346640-08-2
MW378.45
Purity>98% (HPLC)
FormulaC15H10N2O4S3
SMILESS1C(=S)N(C(=O)/C/1=C\c1ccc(s1)[N+](=O)[O-])c1ccc(cc1)OC
TargetEGFR
SolubilityDMSO : ≥ 30 mg/mL; 79.27 mM

Bioactivity

In Vivo
Animal model: C57BL/KaLwRij mice of 6 to 8 weeks of age with 5TGM1-luc. Dosage: 10 mg/kg. Administration: i.p.; three times a week; for 24 days. Result: Significantly prolonged life of 5TGM1-luc–bearing mice and suppressed 5TGM1-luc growth as determined by life imaging.
In Vitro
Western blot analysis. Cell line: MM1.S cells Concentration: 3 μM. Incubation time: 0.5, 1, 2, 4, 6 hours Result: Increased PERK dimerization by phosphorylation and IRE1-α oligomerization within 30 minutes in KMS-12-PE confirming accumulation of misfolded ER proteins.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CCF-642 | CCF 642 | CCF642

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  • CCF642 [orb1300453]

    99.57% (May vary between batches)

    346640-08-2

    378.45

    C15H10N2O4S3

    2 mg, 1 mg, 1 ml x 10 mM (in DMSO), 10 mg, 100 mg, 5 mg, 200 mg, 25 mg, 50 mg
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CCF642 (orb1223142)

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Available Sizes

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2 mg
$ 90.00
5 mg
$ 130.00
10 mg
$ 170.00
25 mg
$ 300.00
50 mg
$ 500.00
100 mg
$ 710.00
500 mg
$ 1,540.00