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CDK6/9-IN-2

SKU: orb3136364

Description

CDK6/9-IN-2 is a highly potent dual inhibitor of CDK6 (IC50 = 15 nM) and CDK9 (IC50 = 22 nM) with selectivity over CDK2, CDK8, and CDK11. It suppresses proliferation in IFN-γ/TNF-α-induced HaCaT cells and inhibits the STAT3 pathway and expression of inflammatory factors. CDK6/9-IN-2 alleviates psoriasis dermatitis and is applicable in psoriasis research.

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Key Properties

CAS Number3068529-24-5
MW480.01
FormulaC25H30ClN7O
SMILESO[C@@H]1CN(C2=CC=C(NC3=NC(NC4=CC=C(C=C4)N5CCN(C)CC5)=NC=C3Cl)C=C2)CC1
TargetSTAT,Interleukin,CDK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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CDK6/9-IN-2 (orb3136364)

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