Cart summary

You have no items in your shopping cart.

Cephaeline

SKU: orb1297429

Description

Cephaeline

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number483-17-0
MW466.61
Purity99.45%
FormulaC28H38N2O4
SMILES[H][C@@]12C[C@H](C[C@H]3NCCc4cc(O)c(OC)cc34)[C@@H](CC)CN1CCc1cc(OC)c(OC)cc21
TargetInfluenza Virus,Virus Protease,HIF,ROS,Reactive Oxygen Species,Anti-infection,Ferroptosis,Nrf2
SolubilityEthanol:33.33 mg/mL (71.43 mM);DMSO:100 mg/mL (214.31 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.57 mM)

Bioactivity

In Vitro
We compared the transcriptomes of primary CLL cells cocultured or not with protective bone marrow stromal cells (BMSCs) and found that oxidative phosphorylation, mitochondrial function, and hypoxic signaling undergo most significant dysregulation in non-protected CLL cells, with the changes peaking at 6-8 h, directly before induction of apoptosis. A subset of CLL patients displayed a gene expression signature resembling that of cocultured CLL cells and had significantly worse progression-free and overall survival. To identify drugs blocking BMSC-mediated support, we compared the relevant transcriptomic changes to the Connectivity Map database. Correlation was found with the transcriptomic signatures of the cardiac glycoside ouabain and of the ipecac alkaloids emetine and Cephaeline. These compounds were highly active against protected primary CLL cells (relative IC50's 287, 190, and 35 nM, respectively) and acted by repressing HIF-1α± and disturbing intracellular redox homeostasis. We tested emetine in a murine model of CLL and observed decreased CLL cells in peripheral blood, spleen, and bone marrow, recovery of hematological parameters and doubling of median survival (31.5 vs. 15 days, P = 0.0001).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Zika, phenolic, Virus Protease, VirusProtease, virus, NSC32944, NSC-32944, Inhibitor, NSC 32944, inhibit, Influenza Virus, InfluenzaVirus, Filovirus, HIF-1α, HIF-1, alkaloid, Cephaeline, Ebola

Similar Products

  • Cephaeline dihydrobromide [orb1992074]

    466.622

    C28H38N2O4

    1 mg, 5 mg
  • Cephaeline hydrochloride [orb1303374]

    99.99% (May vary between batches)

    3738-70-3

    503.07

    C28H39ClN2O4

    50 mg, 100 mg, 2 mg, 1 ml x 10 mM (in DMSO), 1 mg, 5 mg, 10 mg, 25 mg
  • Cephaeline dihydrochloride [orb1679052]

    99.67% (May vary between batches)

    5853-29-2

    539.53

    C28H40Cl2N2O4

    5 mg, 1 ml x 10 mM (in DMSO), 10 mg, 25 mg, 1 mg
  • Cephaeline dihydrobromide [orb2653811]

    >98% (HPLC)

    6014-81-9

    628.5

    C28H40Br2N2O4

    100 mg, 50 mg, 10 mg
  • Cephaeline [orb1217992]

    >98% (HPLC)

    483-17-0

    466.6

    C28H38N2O4

    500 mg, 200 mg, 100 mg, 5 mg, 1 g
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Cephaeline (orb1297429)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 170.00
5 mg
$ 320.00
1 ml x 10 mM (in DMSO)
$ 330.00
10 mg
$ 480.00
25 mg
$ 730.00
50 mg
$ 1,020.00
100 mg
$ 1,330.00
200 mg
$ 1,810.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry