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CGP60474

SKU: orb1308460

Description

CGP60474 is a potent small molecule inhibitor targeting VEGFR-2 (IC50 = 84 nM), ATP-competitive PKC, and cyclin-dependent kinases (CDKs). Its anti-endotoxemic activity makes it a valuable research tool for studying angiogenesis, cell cycle progression, and inflammatory responses in both cellular and animal models.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction

Images & Validation

Key Properties

CAS Number164658-13-3
MW355.82
Purity98.15%
FormulaC18H18ClN5O
SMILESOCCCNc1cc(ccn1)-c1ccnc(Nc2cccc(Cl)c2)n1
TargetCDK,PKC,VEGFR
SolubilityDMSO:117.5 mg/mL (330.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.62 mM);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

Target IC50
CDK5-p25:10 nM|CDK2-CyclinA:4 nM|CDK4-CyclinD:216 nM|CDK2-CyclinE:3 nM|CDK9-CyclinT:13 nM|VEGFR2:84 nM|CDK7-CyclinH:200 nM|CDK1-CyclinB:26 nM
In Vivo
In the LPS endotoxemia model, CGP60474 (10 mg/kg; i.p.) inhibits the IL-6 level and increases the survival rate.
In Vitro
The IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/CyclinB, CDK2/CyclinE, CDK2/CyclinA, CDK5/p25, CDK7/CyclinH, CDK4/CyclinD and CDK9/cycT, respectively.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, LPS, IL-6 level, Inhibitor, endotoxemic, ATP-competitive, CDK1/CyclinB, CDK2/CyclinE, CDK2/CyclinA, CDK, CDK4/CyclinD, CDK5/p25, CDK7/CyclinH, CGP60474, CGP-60474, CGP 60474, CDK9/cycT, Cyclin dependent kinase, survival, Protein kinase C, PKC, selective, VEGFR2, VEGFR-2
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

CGP60474 (orb1308460)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
$ 70.00
2 mg
$ 80.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 120.00
10 mg
$ 140.00
25 mg
$ 240.00
50 mg
$ 390.00
100 mg
$ 620.00
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