Chelerythrine chloride

SKU: orb1225131

Description

Chelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK, also inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 uM and displaces Bax from Bcl-XL; inhibits LPS-induced TNF-α level and NO production in LPS-induced murine peritoneal macrophages through selective inhibition of p38 MAPK and ERK1/2 activation; triggers apoptosis via direct action on mitochondria.

Images & Validation

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Key Properties

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CAS Number	3895-92-9
MW	383.8249
Purity	>98% (HPLC)
Formula	C₂₁H₁₈ClNO₄
SMILES	C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]
Target	Bcl-2
Solubility	DMSO: ≥ 3.9 mg/mL

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Broussonpapyrine chloride | NSC 646662

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Gene Symbol

Bcl-2

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