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CHIKV-IN-2

SKU: orb1298126

Description

CHIKV-IN-2

Research Area

Infectious Disease & Virology, Metabolism Research

Images & Validation

Key Properties

CAS Number2361289-44-1
MW362.46
Purity98.67%
FormulaC23H26N2O2
SMILESCOc1cc2CCCCCc2cc1C(=O)Nc1ccc(cc1)C(C)(C)C#N
TargetDehydrogenase,Anti-infection
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.1 mM);DMSO:99 mg/mL (273.13 mM)

Bioactivity

Target IC50
DHODH:270 nM (EC90; Chikungunya virus)
In Vivo
CHIKV-IN-2 (40 mg/kg; p.o., i.p., s.c.) exhibits moderate bioavailability (F=41%, 43%, 4%), terminal elimination half-life (t1/2=9.9, 18.5, 18.6 h) and Cmax (642, 858, 90 ng/mL) in mice. CHIKV-IN-2 (80 mg/kg; i.p. twice a day for 3 days) significantly decreases infectious CHIKV dissemination to other tissues of mice. CHIKV-IN-2 (1 mg/kg; i.v.) exhibits terminal elimination half-life (t1/2= 2.02 h) and AUC (497 h ng/mL) in mice.
In Vitro
CHIKV-IN-2 is active against alphavirus VEEV (EC90=0.40 μM) as well as flaviviruses such as West Nile Virus (WNV, EC90=0.20 μM) and Dengue Virus Strain-2 (DENV-2, EC90=0.60 μM). CHIKV-IN-2 is a potent pan-alphavirus inhibitor, with EC90s of 0.85-2.5 μM for CHIKV clinical isolates and attenuated vaccine strains.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Chikungunya, CHIKV, CHIKV IN 2, CHIKVIN2, CHIKV-IN-2, DHODH, Dihydroorotate Dehydrogenase, Inhibitor, inhibit, virus
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Key Properties

No computed properties available.

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CHIKV-IN-2 (orb1298126)

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Step 2: Enter the in vivo formulation

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 140.00
5 mg
$ 140.00
10 mg
$ 180.00
25 mg
$ 290.00
50 mg
$ 420.00
100 mg
$ 580.00
200 mg
$ 740.00
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