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Chimmitecan

SKU: orb1689819

Description

Chimmitecan is a potent topoisomerase I inhibitor derived from camptothecin. It demonstrates significant antitumor efficacy in both in vitro cellular assays and in vivo animal models, making it a valuable compound for oncology research and anticancer drug development studies.

Research Area

Molecular Biology

Images & Validation

Key Properties

CAS Number185425-25-6
MW404.42
Purity98.35% (May vary between batches)
FormulaC23H20N2O5
SMILESC(C)[C@]1(O)C2=C(C(=O)N3C(=C2)C=4C(C3)=CC=5C(N4)=CC=C(O)C5CC=C)COC1=O
TargetTopoisomerase
SolubilityDMSO:4.05 mg/mL (10.01 mM)

Bioactivity

In Vivo
Chimmitecan (i.v. administration, twice for HCT-116 and thrice for the other tumors per week) caused a dramatic and dose-dependent suppression of tumor growth in all four tumor models. At a dosage of 15 mg/kg, the T/C (%) values were 17.6% (HCT-116), 24.2% (MDA-MB-435), 28.2% (BEL-7402), and 23.0% (A549). when given thrice per week for 2 weeks, chimmitecan (orally administration) inhibited the growth of the A549 xenograft at dosages as low as 4.5 mg/kg, and significant antitumor activity was observed at a dosage of 9 mg/kg.
In Vitro
Chimmitecan was highly cytotoxic (IC50s in the nanomolar range) to a wide variety of tumor cells, including leukemia, lung cancer, gastric cancer, hepatocellular cancer, colon cancer, breast cancer, ovarian cancer, and cervical cancer, and rhabdomyosarcoma cells.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Chimmitecan, (S)-9-Allyl-10-hydroxycamptothecin, 9-Allyl-10-hydroxycamptothecin, topoisomerase I

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Key Properties

No computed properties available.

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Chimmitecan (orb1689819)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
$ 70.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 120.00
10 mg
$ 160.00
25 mg
$ 290.00
50 mg
$ 420.00
100 mg
$ 640.00
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