Cilnidipine

SKU: orb1310660

Description

Cilnidipine (FRC-8653) is a dual L/N-type calcium channel blocker with antihypertensive properties. Its sympatholytic and neuroprotective effects are utilized in cardiovascular and neurological research, including studies on hypertension and stroke models in vivo and in cellular assays in vitro.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

−

Key Properties

−

CAS Number	132203-70-4
MW	492.52
Purity	>99.99% (May vary between batches)
Formula	C₂₇H₂₈N₂O₇
SMILES	COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OC\C=C\C1=CC=CC=C1
Target	Calcium Channel
Solubility	DMSO:262.5 mg/mL (532.97 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.06 mM);Ethanol:4.9 mg/mL (9.95 mM)

Bioactivity

−

In Vivo

Cilnidipine at 10 mM can inhibit the increase in the ratio induced by 40 mM potassium chloride, and is also effective in inhibition when treated with omega-conotoxin GVIA.

In Vitro

Cilnidipine inhibits the rise in blood urea nitrogen and the decline in creatinine clearance, as well as the progression of glomerulosclerosis. It prevents the increased content of renal angiotensin II, the expression of NADPH oxidase, and the augmented membrane translocation of dihydroethidium in SHR/ND rats. Administering 30 mg/kg of Cilnidipine daily to Dahl salt-sensitive rats effectively treated the elevation of systolic blood pressure. Compared to control-treated Dahl S rats, Cilnidipine reduced plasma norepinephrine levels and plasma renin activity. In spinal cord destruction rats, it suppressed the pressor responses induced by sympathetic nerve stimulation and angiotensin II. In anesthetized rats, Cilnidipine, or omega-conotoxin MVIIA, lowered mean arterial blood pressure with a slight increase in heart rate. At antihypertensive doses in rats, Cilnidipine affected sympathetic nerve N-type calcium channels (Ca(2+)), besides vascular L-type channels. Following NMDA receptor activation, Cilnidipine reduced Ca(2+) influx through N-type channels, and in rats in vivo, it protected neurons from ischemic reperfusion injury in the retina. Compared to amlodipine-treated spontaneously hypertensive rats/ND mcr-cp (SHR/ND), Cilnidipine significantly prevented the increase in fibrillary protein staining and restored the expression of podocin and nephrin in the glomeruli.

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Antihypertensive, Ca channels, Ca2+ channels, Calcium Channel, CalciumChannel, Cilnidipine, channel, dihydropyridine Ca, Dual L-and N-type calcium channel, long-acting, inhibit, FRC 8653, FRC8653, FRC-8653, Inhibitor

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

5282138 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Cilnidipine (orb1310660)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

Purity:	>98% (HPLC)
CAS Number:	132203-70-4
MW:	492.5
Formula:	C₂₇H₂₈N₂O₇

Cilnidipine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Cilnidipine-d7 [orb3138306]

Cilnidipine [orb1226543]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Cilnidipine (orb1310660)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors