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CL2-SN-38

SKU: orb1710034

Description

CL2-SN-38 is a linker-payload designed for conjugation to the anti-Trop-2 antibody hRS7 to form an antibody-drug conjugate (ADC). Its SN-38 component is a potent topoisomerase I inhibitor, enabling the targeted delivery of cytotoxic activity. This construct is utilized in oncology research for evaluating ADC efficacy in both in vitro and in vivo models.

Images & Validation

Key Properties

CAS Number1036969-20-6
MW1627.79
FormulaC82H106N12O23
SMILESCCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OC(=O)OCc4ccc(NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc5ccccc5)NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCn5cc(CNC(=O)C6CCC(CN7C(=O)C=CC7=O)CC6)nn5)cc4)c3=O)-c2nc2ccc(O)cc12
TargetDrug-Linker Conjugates for ADC

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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CL2-SN-38 (orb1710034)

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