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Clavulanic Acid

SKU: orb1705935

Description

Clavulanic Acid (RX-10100) is a β-lactamase inhibitor isolated from Streptomyces clavuligerus. It is used in research to study bacterial resistance mechanisms and is commonly combined with β-lactam antibiotics for in vitro susceptibility testing and in vivo infection model studies.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number58001-44-8
MW199.16
Purity99.45%
FormulaC8H9NO5
SMILES[H][C@@]12CC(=O)N1[C@@H](C(O)=O)\C(O2)=C\CO
TargetAntibacterial,Antifungal,Antibiotic
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (5.02 mM);DMSO:10 mg/mL (50.21 mM)

Bioactivity

In Vivo
In C57BL/6 mice with Pseudomonas aeruginosa pneumonia, intraperitoneal injection of clavulanic acid (13 mg/kg) reduces bacterial burden in the lungs. In C57BL/6 mice infected with Ab51, intraperitoneal injection of clavulanic acid (13 mg/kg) shows a half-life (t1/2) of 6.69 hours and an area under the curve (AUC) of 4.03 mg·h/L in a lung infection model. In a rat model of carrageenan-induced paw edema, intraperitoneal injection of clavulanic acid (100-300 mg/kg) exhibits anti-inflammatory effects.
In Vitro
Clavulanic acid exhibits synergistic antibacterial activity with ampicillin against microorganisms producing β-lactamase. Clavulanic acid inhibits strains Ab11 and Ab51 with a minimum inhibitory concentration (MIC) ranging from 2 to 8 μg/mL.

Storage & Handling

Storagestore at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Clavulanic Acid, BRL 14151, BRL14151, BRL-14151, Fungal, MM 14151, MM14151, MM-14151, RX-10100, β-Lactamase

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Key Properties

No computed properties available.

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Clavulanic Acid (orb1705935)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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2 mg
$ 80.00
5 mg
$ 90.00
10 mg
$ 110.00
25 mg
$ 160.00
50 mg
$ 210.00
DispatchUsually dispatched within 5-10 working days
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