Clematichinenoside AR

SKU: orb1297421

Description

Clematichinenoside AR is a bioactive small molecule with demonstrated anti-inflammatory and immunosuppressive properties. It exhibits anti-arthritic effects in collagen-induced arthritis models by modulating the PI3K/Akt signaling pathway and suppressing TNF-α, making it a useful research tool for immunology and rheumatology studies.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	761425-93-8
MW	1807.92
Purity	99.69% (May vary between batches)
Formula	C₈₂H₁₃₄O₄₃
SMILES	[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O[C@@H]4OC[C@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O[C@@H]5OC[C@@H](O[C@@H]6O[C@H](CO)[C@@H](O[C@@H]7O[C@H](CO[C@@H]8O[C@@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@@H](O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@@H](O)[C@H]5O)[C@H]4O)C(C)(C)[C@]3([H])CC[C@@]12C)C(=O)O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O
Target	TNF,Autophagy

Bioactivity

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In Vitro

C-AR was incubated with the content of the large intestine. The culture solution was collected at different time points and analyzed for the metabolites of C-AR. Eight metabolites were identified by liquid chromatography/quadrupole time-of-flight mass spectrometry. M1, M2 and M5 were the major metabolites. In addition, it was proposed that deglycosylation was the only pathway contributing to the biotransformation of C-AR in rat intestinal microflora.

Storage & Handling

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Storage	keep away from direct sunlight,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Autophagy, atherosclerosis, arthritis, Clematichinenoside AR, inhibit, IL receptor, Inhibitor, HIF, TNF-α, TGFβ

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Compound Identifiers

PubChem CID

11434888 ↗

Key Properties

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No computed properties available.

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