Cot inhibitor-1 hydrochloride

SKU: orb1710002

Description

Cot inhibitor-1 hydrochloride is a potent and selective small molecule inhibitor of TPL2 kinase (IC50 = 28 nM). It effectively suppresses TNF-α production in human whole blood assays (IC50 = 5.7 nM), making it a valuable research tool for studying inflammation and oncology pathways in cellular models.

Research Area

Cell Biology, Signal Transduction

Images & Validation

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Key Properties

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Target	MAPK,TNF
Molecular Weight	589.92
Purity	98.37% (May vary between batches)
Formula	C₂₇H₂₈Cl₃FN₈
SMILES	N#CC1=CN=C2C(Cl)=CC(NCC3=CN(CCN4CCCCCC4)N=N3)=CC2=C1NC5=CC=C(C(Cl)=C5)F.Cl

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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TNF-α, MAP3K, Cot inhibitor-1 Hydrochloride, Cot inhibitor-1 hydrochloride(915365-57-0 Free base)

Quality Guarantee

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Compound Identifiers

PubChem CID

169553363 ↗

Key Properties

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No computed properties available.

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