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Cot inhibitor-2

SKU: orb1710001

Description

This orally active small molecule is a potent and selective inhibitor of Cot (Tpl2/MAP3K8) with an IC50 of 1.6 nM. It effectively suppresses LPS-induced TNF-α production in human whole blood (IC50 = 0.3 µM), making it a valuable tool for investigating inflammatory signaling pathways in both cellular and animal models.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number915363-56-3
MW539.43
Purity99.85%
FormulaC26H25Cl2FN8
SMILESCCN1CCC(CC1)n1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
TargetMAPK,TNF
SolubilityDMSO:40 mg/mL (74.15 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (4.63 mM)

Bioactivity

Target IC50
TNF-α production (human whole blood):0.3 μM|Cot (Tpl2/MAP3K8):1.6 nM
In Vivo
Cot inhibitor-2 (100 mg/kg ; orally ; rats) showed a Cmax of 517 ng/mL (0.89 μM) and AUC of 4841 ng•h/mL. Cot inhibitor-2 (25 mg/kg ; p.o. ; rats) is tested in the LPS-induced TNF-α production model in female Sprague-Dawley rats that Cot inhibitor-2 inhibits LPS-induced TNF-α production by 83%.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Cot inhibitor 2, Cot inhibitor2, Cot inhibitor-2, COT/Tpl2, MAP3K, TNF-α
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Quality Guarantee

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Key Properties

No computed properties available.

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Cot inhibitor-2 (orb1710001)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 110.00
5 mg
$ 210.00
1 ml x 10 mM (in DMSO)
$ 240.00
10 mg
$ 310.00
25 mg
$ 610.00
50 mg
$ 840.00
100 mg
$ 1,170.00
200 mg
$ 1,560.00
DispatchUsually dispatched within 3-5 working days
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