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CU-115

SKU: orb1297961

Description

CU-115 is a potent and selective TLR8 antagonist (IC50 = 1.04 µM) that shows minimal activity against TLR7 (>50 µM). It effectively inhibits R-848-induced TNF-α and IL-1β production in THP-1 cells, making it a valuable tool for studying TLR8-mediated signaling in autoimmune and inflammatory disease research.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2471982-20-2
MW569.21
Purity99.96%
FormulaC21H11F7INO2
SMILESFc1cccc(I)c1C(=O)Nc1ccc(Oc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1
TargetTLR
SolubilityDMSO:45 mg/mL (79.06 mM);10% DMSO+90% Corn Oil:2 mg/mL (3.51 mM)

Bioactivity

Target IC50
TLR8:1.04 μM|TLR7:50 μM
In Vitro
CU-115 (1, 5, and 20 µM) inhibits TLR9 to 10-25% inhibition. CU-115 (5-20 µM) inhibits increases in the activity of type I IFN transcriptional induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD. CU-115 (5-20 µM) abolishes the TNF-α production activated by R848 (1 µg/ml) and represses the expression of IL-1β in hTHP-1 cells. CU-115 does not modulate the NF-kB inhibition induced by Pam2CSK4, Pam3CSK4, LPS, R848, Poly(I:C), and Flic in HEK-293 TLR1/2, TLR2/6, TLR3, and TLR4 cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TLR8, N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide, CU115, CU-115, CU 115
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

CU-115 (orb1297961)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 100.00
5 mg
$ 190.00
1 ml x 10 mM (in DMSO)
$ 230.00
10 mg
$ 280.00
25 mg
$ 460.00
50 mg
$ 620.00
100 mg
$ 840.00
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