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Cyclocurcumin

SKU: orb1682865

Description

Cyclocurcumin

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number153127-42-5
MW368.38
Purity99.62%
FormulaC21H20O6
SMILESC(=C/C1=CC(OC)=C(O)C=C1)\C=2OC(CC(=O)C2)C3=CC(OC)=C(O)C=C3
TargetCYP19A1
SolubilityDMSO:80 mg/mL (217.17 mM)

Bioactivity

In Vitro
Cyclocurcumin (10-40 μM, 18 hours) significantly inhibited LPS-stimulated TNF-α release in Homo sapiens macrophages in a dose-dependent manner . Cyclocurcumin (5-25 μM) concentration-dependently antagonized phenylephrine-induced vasoconstriction in freshly isolated rat aortic rings, with a half-maximal inhibitory concentration (IC50) of 14.9±1.0 μM . Cyclocurcumin (5-25 μM, 30 minutes) dose-dependently inhibited intracellular calcium influx .

Storage & Handling

Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Cyclocurcumin, MPP, NADH, NGF, ROS, TNF-α
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Cyclocurcumin (orb1682865)

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1 mg
$ 160.00
5 mg
$ 330.00
10 mg
$ 470.00
25 mg
$ 740.00
50 mg
$ 1,030.00
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