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Cynaropicrin

SKU: orb1684669

Description

Cynaropicrin, a sesquiterpene lactone from artichoke, exhibits anti-hepatitis C and antitrypanosomal activity. It functions by inhibiting NF-κB activation, disrupting microtubulin and c-Myc signaling, and inducing parthanatos in multiple myeloma cells, supporting its study in oncology and infectious disease research.

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry, Signal Transduction

Images & Validation

Key Properties

CAS Number35730-78-0
MW346.37
Purity96.15%
FormulaC19H22O6
SMILESC=C1[C@@]2([C@@]3([C@@]([C@@H](OC(C(CO)=C)=O)CC(=C)[C@@]2(C[C@@H]1O)[H])(C(=C)C(=O)O3)[H])[H])[H]
TargetNF-κB,MMP,TNF,HCV Protease,Microtubule Associated
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.77 mM);DMSO:30 mg/mL (86.61 mM)

Bioactivity

In Vitro
Cynaropicrin effectively reduces the accumulation of NO released by RAW264.7 cells stimulated with lipopolysaccharide and interferon-γ in a dose-dependent manner.

Storage & Handling

Storagestore at low temperature,store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Cynaropicrin, HCV Protease, HCV, HCVProtease, IL Receptor, Microtubule Associated, MicrotubuleAssociated, NFkB, NF-κB, NFκB, NF-kB, NO Synthase, TNF-α, Tubulin

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Key Properties

No computed properties available.

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Cynaropicrin (orb1684669)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 mg
$ 100.00
5 mg
$ 180.00
10 mg
$ 270.00
1 ml x 10 mM (in DMSO)
$ 320.00
25 mg
$ 420.00
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