Cynomolgus Integrin alpha 3 beta 1 (ITGA3&ITGB1) Heterodimer Protein, His Tag&Tag Free

SKU: orb2999595

Description

Integrin alpha 3 beta 1 is a crucial receptor involved in various biological processes, including cell adhesion, migration, and invasion. It is composed of an alpha subunit (ITGA3) and a beta subunit (ITGB1), which together form the integrin alpha 3 beta 1 complex. This complex plays a significant role in the formation of invadopodia, which are cell membrane protrusions that facilitate cell invasion. The integrin alpha 3 beta 1 complex interacts with various extracellular matrix proteins, such as fibronectin, laminin, and collagen, and is involved in processes like matrix degradation and cell invasion. It is also implicated in the maturation of integrin beta 1, which is essential for cell survival and growth.

Research Area

Immunology & Inflammation

Images & Validation

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Application Notes

Cynomolgus ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free produced by co-expression of ITGA3 and ITGB1, has a calculated MW of 127.5 kDa (ITGA3) & 83.6 kDa (ITGB1). Subunit ITGA3 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The protein has a calculated MW of 113.1 kDa (ITGA3) & 83.6 kDa (ITGB1). The protein migrates as 110-150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

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Expression System	HEK293
Target	Integrin alpha 3 beta 1
Reactivity	Monkey
Tag	C-10×His \| Native
Molecular Weight	113.1 kDa (ITGA3) & 83.6 kDa (ITGB1)
Expression Region	Phe 30 - Glu 988 (ITGA3) & Gln 161 - Asp 868 (ITGB1)
Purity	90%
Endotoxins	1.0 EU per μg
Conjugation	Unconjugated

Storage & Handling

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Storage	-20°C
Form/Appearance	Powder
Buffer/Preservatives	50 mM Tris, 150 mM NaCl, pH 7.5
Expiration Date	6 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

Integrin alpha 3 beta 1

UniProt

A0A2K5VFM7, A0A7N9D0D7

RefSeq:ITGB1, A0A2K5VFM7, A0A7N9D0D7, ITGA3

UniProt Details

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No UniProt data available

NCBI Reference Sequences

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Associated Accession Numbers

Curated reference sequences for the gene transcript and protein product

RefSeq	ITGB1, A0A2K5VFM7, A0A7N9D0D7, ITGA3

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