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CZEN-002

SKU: orb1940956

Description

CZEN-002 is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.(In Vitro):α-MSH modulates CNS inflammation by acting directly on melanocortin receptors in glial cells. α-MSH modulates NFκB activation. α-MSH inhibits translocation of transcription factor κB to the nucleus.(In Vivo):α-MSH (50 μg/0.2 ml saline; i.p.) given systemically effectively modulates inflammatory reactions.

Images & Validation

Key Properties

CAS Number581-05-5
MW1664.88
Purity>98% (HPLC)
FormulaC77H109N21O19S
SMILESOC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc2cncn2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc5cnc4ccccc45)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N6CCC[C@H]6C(=O)N[C@H](C(N)=O)C(C)C
TargetAdenylate Cyclase
SolubilityH2O:50 mg/mL (30.03 mM; Need ultrasonic)

Bioactivity

In Vivo
Animal model: IL-10–deficient mice. Dosage: 50 μg/0.2 ml saline. Administration: i.p. Result: Given systemically effectively modulated inflammatory reactions.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

α-Melanocyte-Stimulating Hormone (MSH) amide

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Protocol Information

CZEN-002 (orb1940956)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

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200 mg
500 mg
5 mg
$ 220.00
10 mg
$ 360.00
25 mg
$ 590.00
50 mg
$ 830.00
100 mg
$ 1,190.00