Dabigatran

SKU: orb1225680

Description

A reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM; an anticoagulant agent used to prevent stroke with atrial fibrillation.Thrombosis Approved(In Vitro):Dabigatran (BIBR 953) shows concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human platelet-poor plasma at concentrations of 0.23, 0.83 and 0.18 μM, respectively.(In Vivo):Dabigatran (0.01-0.1 mg/kg; i.v.) inhibits clot formation with an ED50 of 0.033 mg/kg in Wessler model.

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Key Properties

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CAS Number	211914-51-1
MW	471.5111
Purity	>98% (HPLC)
Formula	C₂₅H₂₅N₇O₃
SMILES	CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N
Target	Thrombin
Solubility	DMSO: < 1 mg/mL; H2O: < 1 mg/mL

Bioactivity

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In Vivo	Dabigatran (0.01-0.1 mg/kg; i. v.) inhibits clot formation with an ED50 of 0.033 mg/kg in Wessler model. Animal model: Male rats (Wessler model). Dosage: 0.01, 0.03, 0.05 and 0.1 mg/kg. Administration: Intravenous injection. Result: Inhibited clot formation with an ED50 of 0.033 mg/kg.
In Vitro	Dabigatran (BIBR 953) shows concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human platelet-poor plasma at concentrations of 0.23, 0.83 and 0.18 μM, respectively.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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BIBR 953 | BIBR 953ZW | BIBR953 | BIB-953

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Thrombin

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Dabigatran (orb1225680)

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Applications:	ELISA, FA, FACS, In vivo
Reactivity:	All
Species/Host:	Human Humanized
Clonality:	Monoclonal
Conjugation:	Unconjugated

Applications:	ELISA
Reactivity:	All
Species/Host:	Mouse
Clonality:	Monoclonal
Conjugation:	Unconjugated

Purity:	97.07% (May vary between batches)
CAS Number:	429658-95-7
MW:	499.56
Formula:	C₂₇H₂₉N₇O₃

Purity:	99.34% (May vary between batches)
CAS Number:	41263-74-5
MW:	196.16
Formula:	C₈H₈N₂O₄

Purity:	98.70% (May vary between batches)
CAS Number:	211914-50-0
MW:	536.03
Formula:	C₂₇H₃₀ClN₇O₃

Dabigatran

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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