Danofloxacin mesylate

SKU: orb1309151

Description

Danofloxacin mesylate is a synthetic fluoroquinolone antibiotic that inhibits bacterial DNA gyrase. It is used in research to study its antibacterial efficacy in vitro and its pharmacokinetics and treatment of respiratory infections in animal models.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	119478-55-6
MW	453.48
Purity	99.73% (May vary between batches)
Formula	C₁₉H₂₀FN₃O₃·CH₄O₃S
SMILES	O=S(=O)(C)O.C1CC1n1c2cc(c(cc2c(=O)c(c1)C(=O)O)F)N1[C@@H]2CN([C@H](C1)C2)C
Target	Antibacterial,Antibiotic,P-gp,DNA/RNA Synthesis
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.21 mM);DMSO:4.6 mg/mL (10.14 mM)

Bioactivity

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In Vivo	Danofloxacin exhibits a minimum inhibitory concentration (MIC90) of 0.125μg/ml against isolates of Pasteurella haemolytica, Pasteurella multocida, and Haemophilus somnus from both Europe and North America. Read more...
In Vitro	In vivo, Danofloxacin demonstrates a protective effect against Pasteurella multocida (PD50=0.38 mg/kg), Escherichia coli (PD50=0.8 mg/kg), and Salmonella Choleraesuis (PD50=2.42 mg/kg) in mice. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Inhibitor, inhibit, Antibiotic, Bacterial, DNA-gyrase, DNASynthesis, DNA Synthesis, CP 76136-27, Danofloxacin, Danofloxacin mesylate, Danofloxacin Mesylate, RNASynthesis, RNA Synthesis

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Compound Identifiers

PubChem CID

71334 ↗

Key Properties

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No computed properties available.

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