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DDX3-IN-2

SKU: orb1688845

Description

DDX3-IN-2 is a potent and selective inhibitor of the ATP-dependent RNA helicase DDX3. It exhibits broad-spectrum antiviral activity and is a valuable research tool for studying infections caused by viruses such as HIV and dengue, with utility in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Neuroscience, Protein Biochemistry

Images & Validation

Key Properties

CAS Number1919828-81-1
MW349.43
FormulaC20H23N5O
SMILESO=C(NC1=CC=C(C=C1)N2N=NC(=C2)CCCC)NC=3C=CC=CC3C
TargetCOX,Antiviral,HIV Protease
SolubilityDMSO:80 mg/mL (228.94 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (9.44 mM)

Bioactivity

Target IC50
DEADbox polypeptide 3 (DDX3):0.3 μM
In Vivo
In animal studies, DDX3-IN-2 was administered via tail vein injection at a dose of 20 mg/kg, which showed good biocompatibility and was well tolerated by Wistar rats. DDX3-IN-2 rapidly shortens the half-life and decreases plasma clearance in an intravenous push (0-25 hours) at a dose of 10 mg/kg.
In Vitro
DDX3-IN-2 is a competitive inhibitor of RNA substrates, and its inhibitory potency decreases with increasing RNA substrate concentration. DDX3-IN-2 was shown to be a potent inhibitor of DEADbox polypeptide 3 (DDX3) with an IC50 of 0.3 μM, and DDX3-IN-2 was inactive against the ATPase activity of DDX3, DDX1 deconjugating enzyme and DENV NS3 deconjugating enzyme.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

HIVProtease, HIV Protease, HIV, DDX3, Antiviral
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Key Properties

No computed properties available.

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Protocol Information

DDX3-IN-2 (orb1688845)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
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% Tween 80 +
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2 mg
$ 190.00
DispatchUsually dispatched within 5-10 working days
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