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dFKBP-1

SKU: orb1987814

Description

dFKBP-1 is a potent PROTAC degrader of FKBP12, constructed by conjugating the SLF ligand for FKBP12 to a thalidomide-based cereblon ligand via a linker. This bifunctional molecule enables targeted protein degradation and is a valuable chemical tool for studying FKBP12 biology in both cellular and in vivo research contexts.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1799711-22-0
MW1009.11
FormulaC53H64N6O14
SMILESO=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCCCNC(CCC(NC4=CC([C@H](OC(=O)[C@H]5N(C(C(C(CC)(C)C)=O)=O)CCCC5)CCC6=CC(OC)=C(OC)C=C6)=CC=C4)=O)=O)=O
TargetPROTACs,FKBP

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Protocol Information

dFKBP-1 (orb1987814)

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