DGCR8 Rabbit mAb [KD Validated] Antibody

SKU: orb1951653

Description

Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs.

Images & Validation

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Item 1 of 2

Tested Applications	ICC, IP, WB
Dilution Range	WB 1:500~1:2000 ICC/IF 1:100~1:500 IP 1:50
Reactivity	Human, Mouse, Rat

Key Properties

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Antibody Type	Recombinant Antibody
Host	Rabbit
Clonality	Monoclonal
Isotype	Rabbit IgG
Immunogen	A synthesized peptide derived from human DGCR8
Purification	Affinity-chromatography
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Form/Appearance	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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DGCR8; DGCRK6; Gy1 ; C22orf12; D16Wis2; pasha;

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DGCR8 Rabbit mAb [KD Validated] Antibody

All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.

Western blot analysis of DGCR8 expression in (1) HEK293 cell lysate; (2) HeLa cell lysate.

Quick Database Links

UniProt

Q8WYQ5

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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ICC

Immunocytochemistry

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Immunoprecipitation

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