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Diethyl-pythiDC

SKU: orb1308385

Description

Diethyl-pythiDC is a small molecule inhibitor of collagen prolyl 4-hydroxylase (C-P4H). This compound is used in biochemical research to study collagen biosynthesis and has applications in investigating fibrotic diseases and connective tissue disorders in both cellular and animal models.

Research Area

Metabolism Research, Protein Biochemistry

Images & Validation

Key Properties

CAS Number1821370-70-0
MW306.34
Purity99.98% (May vary between batches)
FormulaC14H14N2O4S
SMILESCCOC(=O)c1cnc(s1)-c1ccc(cn1)C(=O)OCC
TargetMMP,Hydroxylase
SolubilityDMSO:10 mg/mL (32.64 mM);10% DMSO+90% Corn Oil:1 mg/mL (3.26 mM)

Bioactivity

In Vitro
In MDA-MB-231 cells, Diethyl-pythiDC inhibits CP4H activity in cultured cells at concentrations that do not cause iron deficiency. None of the esterified Diethyl-pythiDC exhibited cytotoxic activity at high micromolar concentrations. Cells treated with dihydroxybenzoate demonstrate a strong iron-deficient phenotype. In contrast, cells treated with Diethyl-pythiDC appear to be normal at concentrations as high as 500 µM. Treatment with Diethyl-pythiDC and low levels of diethyl pyimDC does not affect the level of TfR, HIF-1α, or ferritin.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

collagen prolyl 4-hydroxylase, CP4H, DiethylpythiDC, Diethyl-pythiDC, Diethyl pythiDC, Inhibitor, inhibit
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Key Properties

No computed properties available.

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Diethyl-pythiDC (orb1308385)

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Available Sizes

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1 mg
$ 80.00
5 mg
$ 130.00
1 ml x 10 mM (in DMSO)
$ 140.00
10 mg
$ 190.00
25 mg
$ 360.00
50 mg
$ 580.00
100 mg
$ 820.00
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